Pet animals with cancer help advance human cancer research

Advance Publication Experimental Animals

20 Isoflurane is a representative inhalant anesthesia used in laboratory animals. 21 However, isoflurane mediates respiratory depression and adverse clinical reactions 22 during induction. In the present study, we established a novel balanced anesthesia 23 method in mice that combined isoflurane anesthesia with midazolam and butorphanol 24 (MB). 25 Thirty-four male C57BL/6J mice received either...

Advance Publication Experimental Animals

Comparative breast cancer research, lessons from companion animals

Breast cancer is the most frequent occurring tumor in humans. Current knowledge describes breast cancer as a heterogeneous disease classified in four major categories, i.e. basal-like, ErbB2 enriched, luminal subtype A or luminal subtype B. The majority of human breast cancers are hormone-receptor positive and may respond to endocrine therapy. Our understanding of mammary gland development and ...

FDG PET in the management of lung cancer

We describe a patient with newly diagnosed limy cancer. Staging was performed with CT and mediastinoscopy. FDG PET scan was performed and confirmed increased metabolic activity in the primary tumor as well as the hilar lymph node. Seven months after initial presentation, the patient was found to have two lytic lesions in the pelvis on plain radiograph. Hone scan was negative but PET demon...

Issues pertaining to PET imaging of liver cancer

Positron emission tomography (PET) imaging using 2-deoxy-2-[F-18]fluoro-D-glucose (FDG) has proven valuable in the diagnosis, staging and restaging for many cancers. However, its application for liver cancer has remained limited owing in part to the relatively high background uptake of the tracer in the liver plus the significant variability of the tumor specific uptake in liver cancer among pa...